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Sinus Surgery

NEUROMARK vs ClariFix: Which Is Right for Me?

August 18, 2025

5 minutes

Reviewed by Michael Kaplan, MD

If you’re one of the millions of Americans suffering from chronic rhinitis, you know how exhausting it can be. The runny nose, nasal congestion, postnasal drip, and constant sneezing aren’t just irritating — they interfere with your sleep, your focus, and your quality of life.

At Kaplan Sinus Relief, we specialize in long-lasting solutions for chronic rhinitis that go beyond temporary symptom relief. Two of the most effective treatment options available today are NEUROMARK and ClariFix — both minimally invasive, in-office cryotherapy procedures that target the posterior nasal nerve (PNN) to reduce rhinitis symptoms at the source.

But if you’re deciding between NEUROMARK vs ClariFix, how do you know which is right for you?

In this article, we’ll walk you through what each treatment does, how effective they are, how they differ, and who may benefit most from each option. If you have questions or are ready to discuss treatment, reach out to Kaplan Sinus Relief in Houston for a personalized consultation.

What is NEUROMARK?

NEUROMARK is an advanced cryotherapy procedure that treats chronic rhinitis by targeting the posterior nasal nerve (PNN) — the nerve responsible for regulating nasal secretions. When this nerve is overactive, it can lead to persistent congestion, sneezing, and drainage.

Developed by Neurent Medical, NEUROMARK stands apart for its multi-point mapping system, which allows your ENT to identify multiple nerve branch locations within the nasal cavity and apply customized, low-temperature cryotherapy with precision.

The NEUROMARK procedure:

  • Is done entirely in-office with local anesthesia
  • Takes less than 30 minutes to complete
  • Uses patient-specific mapping to treat more surface area and multiple PNN branches
  • Involves no cutting or nasal packing
  • Requires minimal downtime (most patients return to normal activity within 24 – 48 hours)

NEUROMARK is especially helpful for patients whose rhinitis symptoms have not responded well to medication, sprays, or allergy treatments.

What is the success rate of NEUROMARK?

Clinical studies have shown that over 80% of patients treated with NEUROMARK experience significant and lasting improvements in nasal symptoms. Patients typically report:

  • Less nasal drainage and congestion
  • Fewer flare-ups and allergy-related triggers
  • Better sleep and breathing
  • Reduced dependence on daily medications

Because the procedure is customized to your unique anatomy, NEUROMARK offers greater precision and repeatability, which contributes to its high success rate and growing popularity among ENT specialists and patients alike.

What is the ClariFix procedure?

ClariFix is a cryotherapy-based treatment that also targets the posterior nasal nerve but does so with a single-point application device. It works by freezing the nerve tissue responsible for sending hyperactive signals that cause inflammation and mucus production.

The procedure:

  • Is performed in-office under local anesthesia
  • Takes about 20 minutes
  • Uses a handheld probe to deliver controlled cold therapy to the back of the nasal cavity
  • Involves minimal discomfort (patients may feel pressure or cold)
  • Requires no surgical recovery time

ClariFix is a well-established, FDA-cleared treatment that’s been used for years to treat both allergic and non-allergic rhinitis, especially for patients who are not candidates for surgery or who have failed other forms of treatment.

What is the success rate of ClariFix?

Studies show that ClariFix helps reduce symptoms in approximately 70% of patients, particularly those dealing with:

While results can vary based on the severity and cause of rhinitis, many patients report improvements in symptoms lasting six months or longer, with the possibility of repeat treatments if needed.

What is the difference between NEUROMARK and ClariFix?

Here’s a side-by-side comparison to help you see how NEUROMARK and ClariFix stack up:

FeatureNEUROMARKClariFix
Treatment typeCryotherapy with multi-point targetingCryotherapy with single-point application
Anatomical precisionHigh – uses patient-specific nerve mappingModerate – fixed application point
Treatment duration~30 minutes~20 minutes
Anesthesia requiredLocalLocal
InvasivenessMinimally invasive, no cutting or packingMinimally invasive, no cutting or packing
Recovery time24 – 48 hours24 – 48 hours
Side effectsMild congestion, temporary discomfortTemporary headache, congestion, or bleeding
Success rate~80 – 85%~70 – 75%
FDA clearanceYesYes
AvailabilityOffered at select ENT practicesWidely available
CostVaries; may be covered by insuranceVaries; may be covered by insurance
Best forPatients with moderate to severe or resistant chronic rhinitisPatients with mild to moderate rhinitis or nerve overactivity

As you can see, while both NEUROMARK and ClariFix are effective cryotherapy options for treating chronic rhinitis, there are key differences that may influence your decision:

  • Choose NEUROMARK if you’ve tried ClariFix or medications in the past with limited success, or if your symptoms are more severe or widespread. Its multi-site application and precise nerve targeting make it ideal for patients with complex or stubborn symptoms.
  • Choose ClariFix if you have moderate rhinitis symptoms that haven’t responded to medication, and you’re looking for a quicker, more widely available treatment option with a strong safety record and shorter procedure time.

Dr. Michael Kaplan and the team at Kaplan Sinus Relief will help you weigh these options based on your medical history, symptom severity, and insurance coverage.

Suffering from chronic rhinitis? Kaplan Sinus Relief has the solutions.

Whether your symptoms stem from allergies, environmental triggers, or nerve hypersensitivity, you don’t have to keep living with them. When deciding between NEUROMARK vs ClariFix, remember both are among the most effective non-surgical procedures available today — and at Kaplan Sinus Relief, we’re proud to offer both in our Houston office.

During your consultation, Dr. Kaplan will:

  • Review your sinus and allergy history
  • Perform a comprehensive nasal exam and imaging (if needed)
  • Discuss your symptoms and lifestyle
  • Recommend a personalized treatment plan that includes the right procedure for you

Don’t waste another season struggling with congestion, sneezing, and postnasal drip. Book your appointment with Kaplan Sinus Relief today and take the first step toward long-term relief with NEUROMARK or ClariFix.

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4101 Greenbriar Drive, Suite 320
Houston, TX 77098